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PetPals
Real discussions from product enthusiasts
Regional Flea Resistance Concerns for Frontline Plus
Some users report Frontline Plus has become less effective in recent years, citing flea resistance in specific regions like California and the Southern US. While many still find it effective, this has led others to explore alternative treatments.
Frontline Plus vs. NexGard and Seresto Collars
Discussions frequently compare Frontline Plus to NexGard (oral) and Seresto (8-month collar). Users weigh Frontline Plus's monthly topical application against NexGard's faster action and Seresto's longer duration and tick repellency.
Long-Term User Loyalty Amidst Evolving Treatments
Despite debates about evolving resistance, a segment of long-time users express continued satisfaction with Frontline Plus, some having used it for over 20 years without issues. This highlights a divide between users experiencing resistance and those with consistent positive results.
Expert answers based on real user experience
User experiences with Frontline Plus effectiveness vary geographically, with some users in areas like California, the Southern US, and Northern Virginia reporting reduced efficacy. This is often attributed to the development of flea resistance to the active ingredients, fipronil and (S)-methoprene, over time. While these ingredients target adult fleas, eggs, and larvae, widespread use can lead to selection pressure favoring resistant populations. However, many users in other locales continue to find it reliable for 30 days of protection when applied correctly directly to the skin.
r/dogs discussions
Frontline Plus offers monthly topical application, killing adult fleas, eggs, and larvae with fipronil and (S)-methoprene, and also treats chewing lice. In contrast, oral chews like NexGard are noted for faster action and sometimes broader tick coverage. Seresto collars provide up to 8 months of protection and actively repel ticks, a feature not typical of Frontline Plus. Frontline Plus's mechanism is direct contact killing, whereas others may vary.
r/dogs discussions
Yes, applying topical treatments like Frontline Plus immediately after bathing with flea or tick shampoos may reduce effectiveness. Shampoos can strip the dog's natural skin oils, which are crucial for the proper absorption and spread of the topical solution across the skin's surface. For optimal results, it is generally recommended to wait at least 48 hours after bathing before applying Frontline Plus, ensuring the product can distribute effectively over the skin for its 30-day protection period.
r/dogs discussions
While user forums occasionally raise concerns about potential neurological side effects linked to flea and tick treatments generally, specific, quantified data on the incidence of such events directly attributable to Frontline Plus is not widely published or consistently discussed in community forums. The active ingredients, fipronil and (S)-methoprene, target the insect nervous system, but their specificity to invertebrates is high. Regulatory bodies monitor adverse events, and while rare occurrences are reported across various products, definitive comparative statistics for Frontline Plus versus oral or other topical treatments remain an area of uncertainty for many pet owners.
Community forums, user discussions
Flea resistance to fipronil, a GABA-gated chloride channel blocker, is often theorized to arise from target-site mutations in the insect's nervous system that reduce the drug's binding affinity. Another mechanism could involve enhanced metabolic detoxification, where fleas develop enzymes that break down fipronil more rapidly before it can reach therapeutic concentrations. While (S)-methoprene acts as an insect growth regulator (IGR) by preventing egg hatching and larval development, resistance mechanisms for IGRs can involve altered cuticular penetration or metabolic inactivation, though resistance to fipronil is more commonly cited in user discussions.
Frontline
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Keep your dog protected with the number 1 name in flea & tick protection (1), FRONTLINE. FRONTLINE Plus for Dogs is a fast-acting, long-lasting waterproof flea & tick topical that's proven to kill fleas, flea eggs, flea larvae, chewing lice, and ticks that can transmit Lyme disease. Break the flea life cycle — FRONTLINE Plus for Dogs is specially formulated with fipronil and (S)-methoprene to kill existing adult fleas, flea eggs and flea larvae to guard against further infestations for flea control. Trusted by pet owners for over 20 years (2) — FRONTLINE Plus for Dogs can be used on puppies as young as eight weeks old, weighing 5 pounds or more, and is easy to apply. Applied to a single point on your pet, the flea and tick control treatment covers your dog's entire body and deposits in the sebaceous glands. These glands act as a reservoir, continuously replenishing the treatment onto your pet, working even if your dog gets wet. Just one dose of FRONTLINE Plus each month protects against fleas & ticks for a full 30 days. FRONTLINE Plus also comes in a formula designed for cats and kittens eight weeks of age and older, 1.5lbs. and over so you can protect the dogs or cats in your house from fleas and ticks with FRONTLINE Brand Products. Appropriately treat all pets in your household monthly to effectively control fleas and ticks and prevent the establishment of new flea infestations. Subscribe and save today to make it easier to keep your dogs or cats protected year-round and make sure you never run out of FRONTLINE Plus. Be sure to visit our brand store and follow us to stay up to date on new FRONTLINE products, features, tips and more. References: (1) BI Marketing Excellence Survey performed by Kynetec, November 2023. (2) 20 years of trust in killing fleas and ticks demonstrated by various studies in the past 20 years including a 2002 Pet Owner Brand Awareness and Attitude Tracking Study performed by Bruno and Ridgway Research Associates and the 2023 BrandSpark© American Trust Study where FRONTLINE Brand Products were voted most trusted for brand for flea & tick prevention.
| UPC | 350604287209 666672366389 |
| ASIN | B0002J1FOE |
| GTIN | 350604287209 666672366389 |
| Brand | Frontline |
| Scent | Unscented |
| Volume | 339 Milliliters |
| Item Form | Liquid |
| Brand Name | Frontline |
| Department | Insect Control |
| Scent Name | Unscented |
| Unit Count | 3 Count |
| Item Volume | 339 Milliliters |
| Item Weight | 0.04 Pounds |
| Manufacturer | Boehringer Ingelheim Animal Health |
| Model Number | 72219 |
| Dog Breed Size | Large |
| Item Type Name |
-9%Frontline
FRONTLINE Plus Flea and Tick Treatment for Small Dogs Upto 5 to 22 lbs. 3 Treatments
-9%Frontline
FRONTLINE Plus Flea and Tick Treatment for Cats Over 1.5 lbs. 3 Treatments
FRONTLINE
FrontLine Povidone Iodine Swabs, 10% More Iodine Antiseptic Solution, Cotton Swabsticks for Wound Care, Nasal Cleansing, First Aid & Medical Supplies, Individually Wrapped Box of 50
Scientific literature, expert analysis
| Topical Purple box |
| Target Species | Dog |
| Customer Reviews | 4.4 4.4 out of 5 stars (49,712) 4.4 out of 5 stars |
| Best Sellers Rank | #138 in Pet Supplies (See Top 100 in Pet Supplies) #2 in Dog Flea Drops |
| Item model number | 72219 |
| Active Ingredients | fipronil and (S)-methoprene |
| Product Dimensions | 5.75 x 0.75 x 4.5 inches; 0.64 ounces |
| Included Components | Package includes 3 applicators |
| Allergen Information | Abalone Free |
| Date First Available | September 2, 2004 |
| Warranty Description | only for dog |
| Age Range Description | All Life Stages |
| Age Range (Description) | All Life Stages |
| Manufacturer Part Number | P004FLTSP-45-88 |
| Manufacturer recommended age | 1 month and up |
| Is Discontinued By Manufacturer | No |
| Global Trade Identification Number | 00350604287209 |